Open AccessEffects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries
Author(s) -
Zhang Li,
Liu Lisheng,
Wang Mingyi
Publication year - 2021
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12189
Subject(s) - puerarin , medicine , inflammation , oxidative stress , cardiology , diabetes mellitus , endothelial dysfunction , left ventricular hypertrophy , cognitive decline , type 2 diabetes , ischemia , stroke (engine) , endocrinology , blood pressure , pathology , dementia , disease , mechanical engineering , alternative medicine , engineering
Age‐associated increases in physical and mental stress, known as allostatic load, could lead to a chronic low‐grade inflammation in the heart, brain, and arteries. This low‐grade inflammation potentially contributes to adverse structural and functional remodeling, such as intimal medial thickening, endothelial dysfunction, arterial stiffening, cardiac hypertrophy and ischemia, and cognitive decline. These cellular and tissue remodeling is the fertile soil for the development of age‐associated structural and functional disorders in the cardiovascular and cerebrovascular systems in the pathogenesis of obesity, type II diabetes, hypertension, atherosclerosis, heart dysfunction, and cognitive decline. Growing evidence indicates that puerarin, a polyphenol, extracted from Puerara Labota , efficiently alleviates the initiation and progression of obesity, type II diabetes, hypertension, atherosclerosis, cardiac ischemia, cardiac arrythmia, cardiac hypertrophy, ischemic stroke, and cognition decline via suppression of oxidative stress and inflammation. This mini review focuses on recent advances in the effects of puerarin on the oxidative and inflammatory molecular, cellular, tissue events in the heart, brain, and arteries.