Open AccessCoagulopathy in elderly patients with coronavirus disease 2019
Author(s) -
Yuan Xueting,
Tong Xunliang,
Wang Yan,
Wang He,
Wang Liuming,
Xu Xiaomao
Publication year - 2020
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12133
Subject(s) - coagulopathy , fibrinogen , medicine , d dimer , gastroenterology , covid-19 , prothrombin time , coagulation , c reactive protein , disease , inflammation , infectious disease (medical specialty)
Background Since the outbreak of coronavirus disease 2019 (COVID‐19), clinical features have been analyzed in detail. However, coagulopathy in elderly COVID‐19 patients has been scarcely reported. Methods Coagulation parameters of 189 patients with COVID‐19 in Tongji hospital were retrospectively analyzed among age groups. Results Patients were divided into 2 groups: older group (≥65 years, n = 87) and younger group (<65 years, n = 102). The proportion of patients with elevated fibrinogen (79.0% vs 59.6%, p = .005) and D‐dimer (78.0% vs 55.2%, p = .001) shows the significant difference between the groups. The elderly patients revealed significantly longer prothrombin time (14.0 [13.4–14.4]s vs 13.6 [13.2–14.1]s, p = .026), higher D‐dimer (1.00 [0.5–1.9] μg/mL vs 0.6 [0.3–1.6] μg/mL, p = .013) and fibrinogen (5.2 [4.1–6.2] g/L vs 4.4 [3.4–5.7] g/L, p = .004) levels, compared to the younger group. A positive correlation was observed between the coagulation parameters and inflammatory markers including high‐sensitivity C‐reactive protein and interleukin‐6 ( p < .05). Conclusions The hypercoagulable state is more common in elderly COVID‐19 patients, and coagulopathy is associated with excessive systemic inflammation.