Open AccessPancreatic senescence and its clinical manifestations
Author(s) -
Wang Lu,
Zheng Songbai
Publication year - 2020
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12095
Subject(s) - endocrine system , senescence , pancreas , pancreatic function , diabetes mellitus , enteroendocrine cell , exocrine pancreas , medicine , digestion (alchemy) , function (biology) , endocrinology , physiology , biology , hormone , chemistry , microbiology and biotechnology , chromatography
Abstract The pancreas is a vital organ which has both endocrine and exocrine functions and plays an essential role in food digestion and glucose metabolism. Pancreatic structure and function undergo a series of changes with aging and senescence. Pancreatic exocrine and endocrine function gradually change, which may lead to conditions such as dyspepsia and diabetes mellitus. Hence, clinicians need to be familiar with the characteristics of pancreatic senescence. This article reviews the manifestations of pancreatic senescence and its significance for clinical practice.