Open AccessIron and oxidizing species in oxidative stress and Alzheimer's disease
Author(s) -
Zhao Zhongwei
Publication year - 2019
Publication title -
aging medicine
Language(s) - English
Resource type - Journals
ISSN - 2475-0360
DOI - 10.1002/agm2.12074
Subject(s) - oxidative stress , antioxidant , oxidizing agent , reactive oxygen species , oxidative phosphorylation , neurodegeneration , disease , chemistry , biochemistry , hydroxyl radical , biology , microbiology and biotechnology , medicine , organic chemistry
Iron species can participate in the Fenton or Fenton‐like reaction to generate oxidizing species that can cause oxidative damages to biomolecules and induce oxidative stress in the body. Furthermore, iron accumulation and oxidative stress have been shown to associate with the pathological progression of neurodegenerative disorders, including Alzheimer's disease ( AD ) and Parkinson's disease (PD). In this review, the role of iron species in generating the most deleterious free radical species (ie, hydroxyl radical) and effects of this species in causing oxidative stress in vivo are described. The implications of oxidative stress and the recently recognized cell death pathway (ie, ferroptosis) to AD are addressed. Strategies to combat this neurodegenerative disease, such as iron chelation and antioxidant therapies, and future research directions on this aspect are also discussed.