Open AccessA Uterus‐Inspired Niche Drives Blastocyst Development to the Early Organogenesis (Adv. Sci. 28/2022)
Author(s) -
Gu Zhen,
Guo Jia,
Zhai Jinglei,
Feng Guihai,
Wang Xianning,
Gao Zili,
Li Kai,
Ji Shen,
Wang Leyun,
Xu Yanhong,
Chen Xi,
Wang Yiming,
Guo Shanshan,
Yang Man,
Li Linlin,
Han Hua,
Jiang Liyuan,
Wen Yongqiang,
Wang Liu,
Hao Jie,
Li Wei,
Wang Shutao,
Wang Hongmei,
Gu Qi
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270180
Subject(s) - organogenesis , embryo , blastocyst , endometrium , uterus , microbiology and biotechnology , biology , andrology , conceptus , embryogenesis , pregnancy , medicine , endocrinology , fetus , biochemistry , genetics , gene
Early Organogenesis In vitro culture of embryos is a useful tool to explore the mysteries of life. As the natural platform for embryo development, the uterus inspires the building of in vitro culture conditions. In article number 2202282 by Qi Gu, Hongmei Wang, Shutao Wang, and co‐workers, particularly designed collagen is grafted onto polydimethylsiloxane to simulate the moduli of the endometrium and uterine horn and the microstructure of the endometrium during mouse pregnancy. The uterus‐inspired niche microenvironment controls the migration and assembly of extraembryonic tissues, simulates embryo implantation, and ultimately promotes embryo development to early organogenesis.