Open AccessRecapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip (Adv. Sci. 22/2022)
Author(s) -
Kim Hyunho,
Sa Jason K.,
Kim Jaehoon,
Cho Hee Jin,
Oh Hyun Jeong,
Choi DongHee,
Kang SeokHyeon,
Jeong Da Eun,
Nam DoHyun,
Lee Hakho,
Lee Hye Won,
Chung Seok
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270139
Subject(s) - crosstalk , microfluidics , tumor microenvironment , microfluidic chip , cancer research , lung cancer , circulating tumor cell , cancer cell , cell culture , chip , brain cancer , cancer , nanotechnology , neuroscience , materials science , chemistry , metastasis , biology , pathology , medicine , tumor cells , engineering , electronic engineering , electrical engineering , genetics
Microfluidic Co‐Culture Chip In article number 2201785 by Hye Won Lee, Seok Chung, and co‐workers, development of a microfluidic triculture chip to simulate interactions between brain metastatic tumor cells and the microenvironment of the brain tumor is described. The microfluidic chip allows for the cultivation of patient‐derived cells in complex components of reconstituted brain, as well as the spatial collection of conditioned media and cells for a variety of biological analyses. This innovative platform allows the screening of drugs that target the intercellular communication between metastatic cancer cells and microenvironmental components at the metastatic site.