Open AccessHuman Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing (Adv. Sci. 21/2022)
Author(s) -
Li Zhong,
Lin Zixuan,
Liu Silvia,
Yagi Haruyo,
Zhang Xiurui,
Yocum Lauren,
RomeroLopez Monica,
Rhee Claire,
Makarcyzk Meagan J.,
Yu Ilhan,
Li Eileen N.,
Fritch Madalyn R.,
Gao Qi,
Goh Kek Boon,
O'Donnell Benjamen,
Hao Tingjun,
Alexander Peter G.,
Mahadik Bhushan,
Fisher John P.,
Goodman Stuart B.,
Bunnell Bruce A.,
Tuan Rocky S.,
Lin Hang
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270133
Subject(s) - mesenchymal stem cell , biomedical engineering , crosstalk , adipose tissue , cartilage , synovial fluid , stem cell , drug delivery , medicine , microbiology and biotechnology , pathology , anatomy , biology , osteoarthritis , materials science , nanotechnology , engineering , alternative medicine , electronic engineering
Human Mesenchymal Stem Cell‐Derived Miniature Joint System In article number 2105909 by Rocky S. Tuan, Hang Lin, and co‐workers, a miniature synovial joint‐mimicking system (miniJoint) is established in a microfluidics‐enabled bioreactor, in which human mesenchymal stem cell‐derived bone‐cartilage complex, synovial‐like fibrous tissue, and adipose tissue are integrated and show active crosstalk. The data demonstrate the potential of miniJoint as a new model for the study of joint pathology and the development of novel therapeutic interventions.