Open AccessDynamic Interplay between Structural Variations and 3D Genome Organization in Pancreatic Cancer (Adv. Sci. 18/2022)
Author(s) -
Du Yongxing,
Gu Zongting,
Li Zongze,
Yuan Zan,
Zhao Yue,
Zheng Xiaohao,
Bo Xiaochen,
Chen Hebing,
Wang Chengfeng
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270113
Subject(s) - carcinogenesis , genome , computational biology , human genome , pancreatic cancer , identification (biology) , biology , chromosome , cancer , structural variation , genetics , gene , botany
Carcinogenesis of Structural Variations in Human Cancer In article number 2200818, Hebing Chen, Chengfeng Wang, and co‐workers report carcinogenesis of structural variations (SVs) focusing on their dynamic interplay with three‐dimensional (3D) genome organization with multi‐omics strategies integrating long‐read single‐molecule real‐time (SMRT) sequencing and high‐throughput chromosome conformation capture (Hi‐C) technique in deadly human pancreatic cancer. This work provides a genome‐wide prospects of SVs and 3D genome, and expand current understanding of tumorigenesis, which might facilitate the identification of novel prognostic markers or therapeutic targets.