Open AccessDirecting Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells (Adv. Sci. 17/2022)
Author(s) -
Pahapale Gayatri J.,
Tao Jiaxiang,
Nikolic Milos,
Gao Sammy,
Scarcelli Giuliano,
Sun Sean X.,
Romer Lewis H.,
Gracias David H.
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270110
Subject(s) - multicellular organism , mechanism (biology) , nanotechnology , biophysics , morphology (biology) , extracellular , chemistry , cell , materials science , biology , biochemistry , physics , quantum mechanics , genetics
Directing Multicellular Organization In article number 2104649, Lewis H. Romer, David H. Gracias, and co‐workers report the discovery of an endothelial cell self‐organization mechanism that is guided simply by tuning the aspect ratio of 3D geometry on soft hydrogel substrates. This mechanism is driven by a balance between intra‐ and extracellular interactions and is independent of protein or chemical patterning.