Open AccessBile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis (Adv. Sci. 16/2022)
Author(s) -
Wang Shouli,
Kuang Junliang,
Zhang Hongwei,
Chen Wenlian,
Zheng Xiaojiao,
Wang Jieyi,
Huang Fengjie,
Ge Kun,
Li Mengci,
Zhao Mingliang,
Rajani Cynthia,
Zhu Jinshui,
Zhao Aihua,
Jia Wei
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270105
Subject(s) - bile reflux , bile acid , microbiome , cancer research , carcinogenesis , carcinogen , cancer , stat3 , gastroenterology , medicine , reflux , chemistry , signal transduction , bioinformatics , biology , biochemistry , disease
New Strategy for the Prevention of Gastric Cancer Bile reflux can promote gastric carcinogenesis through activation of the IL‐6/JAK1‐STAT3 signaling pathway. Inhibition of STAT3 by cryptotanshinone can alleviate this carcinogenic effect, thus providing a new strategy for the prevention of gastric cancer associated with bile reflux. More details can be found in article number 2200263 by Aihua Zhao, Wei Jia, and co‐workers.