Open AccessCoupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations (Adv. Sci. 14/2022)
Author(s) -
Sun Na,
Tran Benjamin V.,
Peng Zishan,
Wang Jing,
Zhang Ceng,
Yang Peng,
Zhang Tiffany X.,
Widjaja Josephine,
Zhang Ryan Y.,
Xia Wenxi,
Keir Alexandra,
She JiaWei,
Yu Hsiaohua,
Shyue JingJong,
Zhu Hongguang,
Agopian Vatche G.,
Pei Renjun,
Tomlinson James S.,
Toretsky Jeffrey A,
Jonas Steven J.,
Federman Noah,
Lu Shaohua,
Tseng HsianRong,
Zhu Yazhen
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270091
Subject(s) - extracellular vesicles , click chemistry , extracellular , extracellular vesicle , vesicle , chemistry , coupling (piping) , biophysics , nanotechnology , microbiology and biotechnology , biochemistry , gene , biology , microvesicles , materials science , combinatorial chemistry , membrane , microrna , metallurgy
Extracellular Vesicle In article number 2105853 by Renjun Pei, Shaohua Lu, Hsian‐Rong Tseng, Yazhen Zhu, and co‐workers, an efficient, convenient, and rapid extracellular vesicle (EV) enrichment platform called EV Click Beads is developed by combining lipid labelling and click chemistry‐based capturing. EV Click Beads provides a non‐invasive diagnostic solution for detection of disease status and monitoring treatment response for cancer patients, including Ewing sarcoma, the second most common type of bone cancer in children.