Open AccessIdentification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth (Adv. Sci. 11/2022)
Author(s) -
Xie Jiansheng,
Ma Guolin,
Zhou Lijuan,
He Lian,
Zhang Zhao,
Tan Peng,
Huang Zixian,
Fang Shaohai,
Wang Tianlu,
Lee YiTsang,
Wen Shufan,
Siwko Stefan,
Wang Liuqing,
Liu Jindou,
Du Yangchun,
Zhang Ningxia,
Liu Xiaoxuan,
Han Leng,
Huang Yun,
Wang Rui,
Wang Youjun,
Zhou Yubin,
Han Weidong
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270072
Subject(s) - endoplasmic reticulum , stim1 , rna splicing , glioma , downregulation and upregulation , alternative splicing , chemistry , glioblastoma , microbiology and biotechnology , cancer research , biology , biochemistry , gene , messenger rna , rna
Identification of a STIM1 Splicing Variant In article number 2103940, Guolin Ma, Youjun Wang, Yubin Zhou, Weidong Han, and co‐workers report STIM1β – an endoplasmic reticulum (ER)‐resident protein situating at the ER‐plasma membrane junction – as a novel splicing variant that is aberrantly upregulated in glioblastoma cells but remains low in immune cells. STIM1β contains a 31‐residue extra polypeptide (red switch) that sabotages the intramolecular inhibition machinery to elicit influx of calcium ions (meteor shower), glioma cell growth and migration (analogous to the recent Tonga volcano eruption). Compared to pan‐STIM inhibition that tends to cause undesired immunosuppressive effects, targeting STIM1β might offer a solution for more precise glioblastoma intervention.