Open AccessMultipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated‐Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC (Adv. Sci. 9/2022)
Author(s) -
Mu Weiwei,
Chu Qihui,
Yang Huizhen,
Guan Li,
Fu Shunli,
Gao Tong,
Sang Xiao,
Zhang Zipeng,
Liang Shuang,
Liu Yongjun,
Zhang Na
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270052
Subject(s) - nanodevice , circulating tumor cell , metastasis , hepatocellular carcinoma , cancer research , primary tumor , tumor cells , medicine , cancer , materials science , nanotechnology
Metastasis Prevention In article number 2101472 by Yongjun Liu, Na Zhang, and co‐workers, a “roots and seeds” multipoint costriking strategy is proposed to eliminate primary tumors and associated‐circulating tumor cells (CTCs). The multipoint costriking nanodevice could specifically capture CTCs, dissociate CTC clusters, block the formation of CTC‐neutrophil clusters, and finally kill CTCs and primary tumor cells to prevent metastasis and enhance the therapeutic effect on hepatocellular carcinoma.