Open AccessNano‐enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion (Adv. Sci. 7/2022)
Author(s) -
Wu Sixuan,
Zhang Kaixiang,
Liang Yan,
Wei Yongbin,
An Jingyi,
Wang Yifei,
Yang Jiali,
Zhang Hongling,
Zhang Zhenzhong,
Liu Junjie,
Shi Jinjin
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270045
Subject(s) - glut1 , glucose transporter , glycolysis , zinc , chemistry , cancer research , biophysics , microbiology and biotechnology , endocrinology , medicine , biochemistry , biology , metabolism , insulin , organic chemistry
Tumor Starvation Therapy In article number 2103534 by Zhenzhong Zhang, Junjie Liu, Jinjin Shi, and co‐workers, a “nano‐enabled energy interrupter”‐initiated novel paradigm of tumor starvation therapy is proposed. The energy interrupter shows a preferential tumor systemic energy exhaustion without obvious side effects by synergizing the “Zn 2+ interference”‐mediated glycolysis inhibition and Zn 2+ ‐activating GLUT1 (glucose transporter 1) tumor specific depletion.