Open AccessEstablishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection (Adv. Sci. 7/2022)
Author(s) -
Ma Jie,
liu Jia,
Gao Dunqin,
Li Xiao,
Zhang Qiyu,
Lv Luye,
Wang Yujie,
Li Jun,
Zhu Yunping,
Wu Zhihong,
Hu Hengrui,
Li Yufeng,
Ma Longda,
Liu Qian,
Hu Zhihong,
Zhang Shuyang,
Zhou Yiwu,
Wang Manli,
Leng Ling
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270041
Subject(s) - organoid , induced pluripotent stem cell , pathophysiology , stem cell , covid-19 , biology , nervous system , pathological , microbiology and biotechnology , virology , medicine , neuroscience , pathology , disease , embryonic stem cell , genetics , infectious disease (medical specialty) , gene
Pathophysiological Model of SARS‐CoV‐2 Infection Human‐induced pluripotent stem cell (hiPSC)‐derived skin organoids can be used to investigate the susceptibility of skin cells to SARS‐CoV‐2 infection, providing the possibility to identify various pathological mechanisms and drug screening strategies. In article number 2104192, Shuyang Zhang, Yiwu Zhou, Manli Wang, Ling Leng, and co‐workers, established an experimental skin organoid model from hiPSC with hair follicles and nervous system and proved KRT17+ hair follicles and different types of nervous cells can be infected by SARS‐CoV‐2, providing the evidence for association between COVID‐19 and hair loss.