Open AccessPressure Drives Rapid Burst‐Like Coordinated Cellular Motion from 3D Cancer Aggregates (Adv. Sci. 6/2022)
Author(s) -
Raghuraman Swetha,
Schubert AnnSophie,
Bröker Stephan,
Jurado Alejandro,
Müller Annika,
Brandt Matthias,
Vos Bart E.,
Hofemeier Arne D.,
Abbasi Fatemeh,
Stehling Martin,
Wittkowski Raphael,
Ivaska Johanna,
Betz Timo
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270037
Subject(s) - homogeneous , cancer cell , biophysics , matrix (chemical analysis) , tumor cells , chemistry , materials science , cancer , cancer research , biology , physics , composite material , genetics , thermodynamics
Coordinated Cell Motion In article number 2104808 by Swetha Raghuraman, Timo Betz, and co‐workers, a novel migration phenomenon is presented wherein cancer cells burst out from tumor aggregates as an act of pressure release into the surrounding in‐homogeneous soft extra‐cellular matrix (ECM) made up of collagen. The pressure within tumor aggregates manifests due to cellular swelling, leading to a super‐diffusive coordinated expulsion of cells within 12 hours, directed towards regions providing least mechanical resistance