Open AccessHemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN‐ γ Signaling (Adv. Sci. 5/2022)
Author(s) -
Zhao Ke,
Liu JinFang,
Zhu YaXin,
Dong XiaoMing,
Yin RongHua,
Liu Xian,
Gao HuiYing,
Xiao FengJun,
Gao Rui,
Wang Qi,
Zhan YiQun,
Yu Miao,
Chen Hui,
Ning HongMei,
Zhang CaiBo,
Yang XiaoMing,
Li ChangYan
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270031
Subject(s) - homing (biology) , progenitor cell , haematopoiesis , stem cell , transplantation , bone marrow , cancer research , cxcr4 , immunology , biology , microbiology and biotechnology , medicine , immune system , ecology , chemokine
Hematopoietic Stem and Progenitor Cells In article number 2103838, Xiao‐Ming Yang, Chang‐Yan Li and co‐workers identify a critical regulator‐HEMGN, that is required for hematopoietic stem and progenitor cells (HSPCs) homing, survival, and reconstitution of blood cells during bone marrow transplantation (BMT). HEMGN acts as a protector which limits interferon‐ γ (IFN‐ γ ) signaling by suppressing nuclear Stat1 tyrosine phosphorylation and assists HSPCs to combat the transplantation stress. Targeted Hemgn may be used to improve conditioning regimens and engraftment during bone marrow transplantation.