Open AccessExtracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization (Adv. Sci. 5/2022)
Author(s) -
Shen Minjuan,
Jiao Kai,
Wang Chenyu,
Ehrlich Hermann,
Wan Meichen,
Hao Dongxiao,
Li Jing,
Wan Qianqian,
Tonggu Lige,
Yan Jianfei,
Wang Kaiyan,
Ma Yuxuan,
Chen Jihua,
Tay Franklin R.,
Niu Lina
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270028
Subject(s) - extracellular matrix , mineralization (soil science) , extracellular , ectopic calcification , calcification , chemistry , microbiology and biotechnology , biophysics , biochemistry , biology , medicine , organic chemistry , nitrogen
Extracellular DNA In article number 2103693, Li‐na Niu and co‐workers discuss a fascinating novel function of extracellular DNA as mineralization initiators in ectopic calcification. Extracellular DNAs regulate matrix calcification outside cells and participate in extracellular mineral nucleation and collagen mineralization. This significant discovery enables facile preparation of biomimetic hybrid materials for tissue engineering and provides a potential solution for treatment of diseases associated with ectopic mineralization.