Open AccessModulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System (Adv. Sci. 4/2022)
Author(s) -
Kotla Niranjan G.,
Isa Isma Liza Mohd,
Rasala Swetha,
Demir Secil,
Singh Rajbir,
Baby Becca V.,
Swamy Samantha K.,
Dockery Peter,
Jala Venkatakrishna R.,
Rochev Yury,
Pandit Abhay
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270025
Subject(s) - ulcerative colitis , hyaluronic acid , colitis , enema , intestinal mucosa , intestinal epithelium , medicine , epithelium , inflammation , chemistry , immunology , pathology , anatomy , disease
Colon Mucosa Protecting HA‐Enema System In article number 2103189, Yury Rochev, Abhay Pandit, and co‐workers develop a biphasic HMW‐hyaluronan (HA) enema suspension that protects the dysregulated colitis colon epithelium. The developed HA‐based system modulate the intestinal epithelial junctional proteins and regulatory signalling pathways, resulting in attenuation of inflammation and mucosal protection. Furthermore, the developed system helps restore the dysregulated intestinal barrier functions and helps in distal colitis management.