Open AccessPolydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis (Adv. Sci. 1/2022)
Author(s) -
Li Juanjuan,
Hou Weiliang,
Lin Sisi,
Wang Lu,
Pan Chao,
Wu Feng,
Liu Jinyao
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270006
Subject(s) - dopaminergic , immune system , colitis , reversion , immunology , inflammation , dopamine , chemistry , medicine , microbiology and biotechnology , biology , neuroscience , biochemistry , gene , phenotype
Dopaminergic Immunoregulation In article number 2104006 by Jinyao Liu and co‐workers, the dopaminergic system is exploited to suppress hyperactive immune responses in local inflamed tissues by polydopamine nanoparticles, which stimulate regulatory T lymphocytes and dendritic cells, while inhibit T helper cells to assist the reversion of inflammatory responses. The application of dopaminergic immunoregulation is further disclosed by combining with oral probiotics that can modulate the gut microbiota for treating colitis.