Open AccessSmad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition (Adv. Sci. 1/2022)
Author(s) -
Tang Philip ChiuTsun,
Chung Jeff YatFai,
Xue Vivian Weiwen,
Xiao Jun,
Meng XiaoMing,
Huang XiaoRu,
Zhou Shuang,
Chan Alex SiuWing,
Tsang Anna ChiMan,
Cheng Alfred SzeLok,
Lee TinLap,
Leung KamTong,
Lam Eric W.F.,
To KaFai,
Tang Patrick MingKuen,
Lan HuiYao
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202270005
Subject(s) - myofibroblast , macrophage , transition (genetics) , immunofluorescence , epithelial–mesenchymal transition , tumor microenvironment , staining , cancer associated fibroblasts , cancer research , lewis lung carcinoma , cancer , chemistry , pathology , microbiology and biotechnology , biology , medicine , immunology , tumor cells , antibody , biochemistry , fibrosis , metastasis , in vitro , gene
Macrophage‐Myofibroblast Transition In article number 2101235 Philip Chiu‐Tsun Tang, Patrick Ming‐Kuen Tang, Hui‐Yao Lan, and co‐workers discovered that tumor‐associated macrophages are capable for de novo generating pathogenic cancer‐associated fibroblasts via a direct mechanism macrophage‐myofibroblast transition (MMT), representing a novel therapeutic target in the tumor microenvironment of solid cancers. Here, the macrophages undergoing MMT were coexpressing CAF ( α ‐SMA, red) and macrophage marker (F4/80, green) with nuclei staining (blue), visualized by immunofluorescence with an experimental Lewis lung carcinoma (LLC) model.