Open AccessWireless Non‐Invasive Monitoring of Cholesterol Using a Smart Contact Lens
Author(s) -
Song Hayoung,
Shin Haein,
Seo Hunkyu,
Park Wonjung,
Joo Byung Jun,
Kim Jeongho,
Kim Jeonghyun,
Kim Hong Kyun,
Kim Jayoung,
Park JangUng
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202203597
Subject(s) - contact lens , hyperlipidemia , wireless , lens (geology) , biomedical engineering , biocompatibility , computer science , embedded system , materials science , medicine , engineering , telecommunications , ophthalmology , metallurgy , diabetes mellitus , endocrinology , petroleum engineering
Herein, a wireless and soft smart contact lens that enables real‐time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol‐related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non‐invasive healthcare device.