Open AccessSmart Internal Bio‐Glues
Author(s) -
Zhang Hengjie,
Zhang Jianhua,
Peng Xu,
Li Zhan,
Bai Wanjie,
Wang Tianyou,
Gu Zhipeng,
Li Yiwen
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202203587
Subject(s) - biocompatibility , nanotechnology , smart material , biomedical engineering , wound healing , materials science , surgery , medicine , metallurgy
Although smart bio‐glues have been well documented, the development of internal bio‐glues for non‐invasive or minimally invasive surgery is still met with profound challenges such as safety risk and the lack of deep tissue penetration stimuli for internal usage. Herein, a series of smart internal bio‐glues are developed via the integration of o‐nitrobenzene modified biopolymers with up‐conversion nanoparticles (UCNPs). Upon irradiation by near‐infrared (NIR) light, the prepared smart bio‐glues can undergo a gelation process, which may further induce strong adhesion between tissues under both dry and wet conditions based on multi‐interactions. Moreover, those NIR light‐responsive bio‐glues with deeper tissue penetration ability demonstrate good biocompatibility, excellent hemostatic performance, and the potent ability to accelerate wound healing for both external and internal wounds. This work provides new opportunities for minimally invasive surgery, especially in internal wound healing using smart and robust bio‐glues.