Open AccessBiomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes
Author(s) -
Zeng Yun,
Dou Taotao,
Ma Lei,
Ma Jingwen
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202202384
Subject(s) - photoacoustic imaging in biomedicine , molecular imaging , modalities , contrast (vision) , optical imaging , ultrasound , biomedical engineering , materials science , computer science , nanotechnology , medicine , radiology , optics , computer vision , in vivo , physics , social science , microbiology and biotechnology , sociology , biology
Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificity of PA imaging and to offer diagnostic information for illnesses. The existing PA contrast agents are categorized into two groups in this review: “always‐on” and “turn‐on,” based on their ability to be triggered by target molecules. The present state of these probes, their merits and limitations, and their future development, is explored.