Open AccessGold Nanostrip Array‐Mediated Wireless Electrical Stimulation for Accelerating Functional Neuronal Differentiation
Author(s) -
Yang Hongru,
Su Yue,
Sun Zhaoyang,
Ma Baojin,
Liu Feng,
Kong Ying,
Sun Chunhui,
Li Boyan,
Sang Yuanhua,
Wang Shuhua,
Li Gang,
Qiu Jichuan,
Liu Chao,
Geng Zhaoxin,
Liu Hong
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202202376
Subject(s) - stimulation , functional electrical stimulation , in vivo , neuroscience , cellular differentiation , biomedical engineering , wireless , materials science , computer science , medicine , biology , telecommunications , biochemistry , microbiology and biotechnology , gene
Neural stem cell (NSC)‐based therapy holds great promise for the treatment of neurodegenerative diseases. Presently, however, it is hindered by poor functional neuronal differentiation. Electrical stimulation is considered one of the most effective ways to promote neuronal differentiation of NSCs. In addition to surgically implanted electrodes, traditional electrical stimulation includes wires connected to the external power supply, and an additional surgery is required to remove the electrodes or wires following stimulation, which may cause secondary injuries and infections. Herein, a novel method is reported for generation of wireless electrical signals on an Au nanostrip array by leveraging the effect of electromagnetic induction under a rotating magnetic field. The intensity of the generated electrical signals depends on the rotation speed and magnetic field strength. The Au nanostrip array‐mediated electric stimulation promotes NSC differentiation into mature neurons within 5 days, at the mRNA, protein, and function levels. The rate of differentiation is faster by at least 5 days than that in cells without treatment. The Au nanostrip array‐based wireless device also accelerates neuronal differentiation of NSCs in vivo. The novel method to accelerate the neuronal differentiation of NSCs has the advantages of wireless, timely, localized and precise controllability, and noninvasive power supplementation.