Open AccessOxygen‐Independent Sulfate Radical for Stimuli‐Responsive Tumor Nanotherapy
Author(s) -
Ding Dandan,
Mei Zihan,
Huang Hui,
Feng Wei,
Chen Liang,
Chen Yu,
Zhou Jianqiao
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202200974
Subject(s) - reactive oxygen species , hydrogen peroxide , oxygen , chemistry , sulfate , nanoparticle , hydrogen sulfide , nanotechnology , materials science , sulfur , biochemistry , organic chemistry
Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H 2 O 2 ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO 5 − )‐loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO 4 − )‐mediated and stimuli‐responsive tumor nanotherapy in an oxygen‐independent manner. In this therapeutic modality, the second near‐infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO 4 − . Different from conventional ROS, the emergence of •SO 4 − , possessing a longer half‐life and more rapid reaction, is independent of the oxygen (O 2 ) and H 2 O 2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli‐responsive nanosystems in biomedicine.