Open AccessFiber‐Optic Theranostics (FOT): Interstitial Fiber‐Optic Needles for Cancer Sensing and Therapy
Author(s) -
Ran Yang,
Xu Zhiyuan,
Chen Minfeng,
Wang Wei,
Wu Yang,
Cai Jiexuan,
Long Junqiu,
Chen ZheSheng,
Zhang Dongmei,
Guan BaiOu
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202200456
Subject(s) - photothermal therapy , optical fiber , photodynamic therapy , photosensitizer , cancer therapy , nanotechnology , computer science , cancer , medicine , biomedical engineering , materials science , chemistry , telecommunications , organic chemistry
Photonics has spurred a myriad of diagnostic and therapeutic applications for defeating cancer owing to its superiority in spatiotemporal maneuverability and minimal harm. The limits of light penetration depth and elusiveness of photosensitizer utilization, however, impede the implementation of the photodiagnostic and ‐therapy for determining and annihilating the deep‐situated tumor. Herein, a promising strategy that harnesses functional optical fibers is developed and demonstrated to realize an in vivo endoscopic cancer sensing and therapy ensemble. Tumor detection is investigated using hypoxia‐sensitive fluorescent fibers to realize fast and accurate tumor recognition and diagnosis. The tumor treatment is further performed by exploiting the endogenous photothermal effect of rare‐earth‐doped optical fibers. The eradication of orthotopic and subcutaneous xenografts significantly validates the availability of tumoricidal fibers. The strategy opens horizons to inspire the design of optical fiber‐mediated “plug and play” precise tumor theranostics with high safety, which may intrigue broader fields, such as fiber optics, materials, chemistry, medicine, and clinics.