Open AccessMultipotent Poly(Tertiary Amine‐Oxide) Micelles for Efficient Cancer Drug Delivery
Author(s) -
Xiang Jiajia,
Shen Yihuai,
Zhang Yifan,
Liu Xin,
Zhou Quan,
Zhou Zhuxian,
Tang Jianbin,
Shao Shiqun,
Shen Youqing
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202200173
Subject(s) - micelle , nanomedicine , drug delivery , chemistry , drug , tertiary amine , internalization , nanotechnology , combinatorial chemistry , pharmacology , biophysics , materials science , cell , nanoparticle , biochemistry , medicine , organic chemistry , biology , aqueous solution
The cancer drug delivery process involves a series of biological barriers, which require the nanomedicine to exhibit different, even opposite properties for high therapeutic efficacy. The prevailing design philosophy, i.e., integrating these properties within one nanomedicine via on‐demand property transitions such as PEGylation/dePEGylation, complicates nanomedicines’ composition and thus impedes clinical translation. Here, polyzwitterionic micelles of poly(tertiary amine‐oxide)‐ block ‐poly( ε ‐caprolactone) (PTAO‐PCL) amphiphiles that enable all the required functions are presented. The zwitterionic nature and unique cell membrane affinity confer the PTAO micelles long blood circulation, efficient tumor accumulation and penetration, and fast cellular internalization. The mitochondrial targeting capability allows drug delivery into the mitochondria to induce mitochondrial dysfunction and overcome tumor multidrug resistance. As a result, the PTAO/drug micelles exhibit potent anticancer efficacy. This simple yet multipotent carrier system holds great promise as a generic platform for potential clinical translation.