Open AccessNeuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y (Adv. Sci. 24/2021)
Author(s) -
Zhang Yan,
Chen ChunYuan,
Liu YiWei,
Rao ShanShan,
Tan YiJuan,
Qian YuXuan,
Xia Kun,
Huang Jie,
Liu XiXi,
Hong ChunGu,
Yin Hao,
Cao Jia,
Feng ShiKai,
He ZeHui,
Li YouYou,
Luo ZhongWei,
Wu Ben,
Yan ZiQi,
Chen TuanHui,
Chen MengLu,
Wang YiYi,
Wang ZhenXing,
Liu ZhengZhao,
Luo MingJie,
Hu XiongKe,
Jin Ling,
Wan TengFei,
Yue Tao,
Tang SiYuan,
Xie Hui
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170165
Subject(s) - osteocyte , neuropeptide y receptor , endocrinology , medicine , bone marrow , mesenchymal stem cell , stromal cell , autonomic nervous system , biology , neuropeptide , osteoblast , microbiology and biotechnology , blood pressure , heart rate , receptor , in vitro , biochemistry
Autonomic Nervous System In article number 2100808 by Yan Zhang, Hui Xie, and co‐workers, osteocyte neuropeptide Y (NPY)‐dependent neuronal control of bone marrow mesenchymal stem/stromal cell (BMSC) fate decision is found. Osteocyte NPY promotes bone marrow adipogenesis at the expense of osteogenesis by BMSC. Osteocyte NPY production is controlled by autonomic nervous system (ANS). γ ‐Oryzanol attenuates ANS dysregulation, NPY overproduction, and bone‐fat imbalance induced by aging and estrogen deficiency.