Open AccessGreen Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma (Adv. Sci. 20/2021)
Author(s) -
Long Kaiqi,
Yang Yang,
Lv Wen,
Jiang Kuan,
Li Yafei,
Lo Amy Cheuk Yin,
Lam Wai Ching,
Zhan Changyou,
Wang Weiping
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170138
Subject(s) - nanocarriers , retinoblastoma , drug , pharmacology , medicine , drug delivery , retinal , chemistry , ophthalmology , nanotechnology , materials science , biochemistry , gene
Light‐Triggered Drug Release In article number 2101754, Changyou Zhan, Weiping Wang, and co‐workers develop an “intravenous injection plus light‐triggered intraocular drug release” strategy to achieve drug accumulation in retinoblastoma. The strategy is demonstrated with a green light‐responsive nanocarrier self‐assembled by photocleavable trigonal molecules. After intravenous injection of drug‐loaded nanocarriers, green light triggers the disassembly of nanocarriers in the retinal blood vessels, which leads to intraocular drug release and accumulation to suppress retinoblastoma growth.