Open AccessIn Vivo Clonal Analysis Reveals Development Heterogeneity of Oligodendrocyte Precursor Cells Derived from Distinct Germinal Zones (Adv. Sci. 20/2021)
Author(s) -
Liu Rui,
Jia Yinhang,
Guo Peng,
Jiang Wenhong,
Bai Ruiliang,
Liu Chong
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170131
Subject(s) - oligodendrocyte , biology , germinal center , brother , precursor cell , myelin , microbiology and biotechnology , neuroscience , genetics , cell , b cell , sociology , anthropology , antibody , central nervous system
Oligodendrocyte Precursor Cells In article number 2102274, Chong Liu and co‐workers describe that oligodendrocyte precursor cells (OPCs) originated from distinct germinal zones undergo distinct cellular destinies. This phenomenon parallels the Greek myth of Gemini twins Castor and Pollux : Ventral germinal zone derived OPCs, resembling mortal brother Castor, will age and eventually die. In contrast, dorsal germinal zone derived OPCs, like the immortal brother Pollux in the myth, continue expand and serve as the pool of oligodendrocytes to provide myelin for neurons (described as the chain grasped in the hands of immortal Pollux).