Open AccessTight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration (Adv. Sci. 19/2021)
Author(s) -
Skamrahl Mark,
Pang Hongtao,
Ferle Maximilian,
Gottwald Jannis,
Rübeling Angela,
Maraspini Riccardo,
Honigmann Alf,
Oswald Tabea A.,
Janshoff Andreas
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170122
Subject(s) - cell migration , tight junction , microbiology and biotechnology , cell , chemistry , biology , biochemistry
Collective Cell Migration In article number 2100478 by Tabea A. Oswald, Andreas Janshoff, and co‐workers, it is shown that tight junction ZO proteins maintain epithelial cell sheet fluidity and thereby ensure efficient collective migration. Cell layers lacking ZO proteins lose viscoelastic integrity due to actomyosin remodeling, inducing a severe mechanical imbalance and increased proliferation. Extremely contractile, small cells emerge in a mechanism reminiscent of a tug of war and particularly impair migration.