Open AccessCollaborative Equilibrium Coupling of Catalytic DNA Nanostructures Enables Programmable Detection of SARS‐CoV‐2 (Adv. Sci. 18/2021)
Author(s) -
Chen Yuan,
Sundah Noah R.,
Ho Nicholas R. Y.,
Natalia Auginia,
Liu Yu,
Miow Qing Hao,
Wang Yu,
Beh Darius L. L.,
Chew Ka Lip,
Chan Douglas,
Tambyah Paul A.,
Ong Catherine W. M.,
Shao Huilin
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170116
Subject(s) - nanostructure , covid-19 , coupling (piping) , nanotechnology , catalysis , dna , virology , materials science , chemistry , biology , medicine , biochemistry , infectious disease (medical specialty) , disease , pathology , metallurgy , outbreak
Programmable Detection of SARS‐CoV‐2 In article number 2101155, Huilin Shao and co‐workers report the collaborative coupling of enzyme–DNA nanostructures to establish multi‐enzyme catalysis. Through programmable nanostructures and favorable equilibrium architecture, the technology achieves direct and sensitive detection of SARS‐CoV‐2 RNA in native patient samples, within 30 minutes at room temperature.