Open AccessChemokine‐Capturing Wound Contact Layer Rescues Dermal Healing (Adv. Sci. 18/2021)
Author(s) -
Schirmer Lucas,
Atallah Passant,
Freudenberg Uwe,
Werner Carsten
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170114
Subject(s) - wound healing , inflammation , chemokine , medicine , immunology
Wound Healing Excessive inflammation often impedes the healing of chronic wounds. In article number 2100293, Lucas Schirmer, Carsten Werner, and co‐workers report a glycosaminoglycan hydrogelcoated wound contact layer capable of selectively sequestering pro‐inflammatory chemokines. A large animal model of human wound healing disorders confirms that the approach dampens inflammation without affecting pro‐regenerative growth factors, thus expanding the scope of a new anti‐inflammatory therapy toward clinical use.