Open AccessDecreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes (Adv. Sci. 16/2021)
Author(s) -
Zhang Jing,
Ni Yueqiong,
Qian Lingling,
Fang Qichen,
Zheng Tingting,
Zhang Mingliang,
Gao Qiongmei,
Zhang Ying,
Ni Jiacheng,
Hou Xuhong,
Bao Yuqian,
KovatchevaDatchary Petia,
Xu Aimin,
Li Huating,
Panagiotou Gianni,
Jia Weiping
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170102
Subject(s) - akkermansia muciniphila , diabetes mellitus , type 2 diabetes , medicine , endocrinology , gut flora , fgf21 , chenodeoxycholic acid , insulin , akkermansia , bile acid , chemistry , fibroblast growth factor , immunology , biochemistry , lactobacillus , receptor , fermentation
New Therapeutic Options for the Treatment of Diabetes In article number 2100536, Huating Li, Gianni Panagiotou, Weiping Jia, and co‐workers demonstrate lean patients with type 2 diabetes have distinct gut microbiota and bile acid profiles. The “Magician” Akkermansia muciniphila connects the gut to pancreas and liver by modulating 3β‐chenodeoxycholic acid and fibroblast growth factor 19, which sheds light on new therapeutic options for the prevention or treatment of diabetes.