Open AccessDrug Delivery: Delivering Antisense Oligonucleotides across the Blood‐Brain Barrier by Tumor Cell‐Derived Small Apoptotic Bodies (Adv. Sci. 13/2021)
Author(s) -
Wang Yulian,
Pang Jiayun,
Wang Qingyun,
Yan Luocheng,
Wang Lintao,
Xing Zhen,
Wang Chunming,
Zhang Junfeng,
Dong Lei
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170079
Subject(s) - blood–brain barrier , apoptosis , in vivo , drug delivery , cancer research , oligonucleotide , chemistry , medicine , microbiology and biotechnology , biology , nanotechnology , materials science , neuroscience , central nervous system , dna , biochemistry
Brain, guarded by the most rigorous barrier — blood‐brain barrier (BBB), is the most critical and sophisticated control center in the body. The dead bodies from melanoma cells, small apoptotic bodies with membrane embedded CD44v6 molecules could pass through BBB and deliver drugs for the cure of Parkinson's disease. The apoptotic body might be a new type of carrier for efficient in vivo drug delivery. More details can be found in article number 2004929 by Chunming Wang, Junfeng Zhang, Lei Dong, and co‐workers.