Open AccessPseudomonas aeruginosa Biofilm: A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms (Adv. Sci. 12/2021)
Author(s) -
Schütz Christian,
Ho DuyKhiet,
Hamed Mostafa Mohamed,
Abdelsamie Ahmed Saad,
Röhrig Teresa,
Herr Christian,
Kany Andreas Martin,
Rox Katharina,
Schmelz Stefan,
Siebenbürger Lorenz,
Wirth Marius,
Börger Carsten,
Yahiaoui Samir,
Bals Robert,
Scrima Andrea,
Blankenfeldt Wulf,
Horstmann Justus Constantin,
Christmann Rebekka,
Murgia Xabier,
Koch Marcus,
Berwanger Aylin,
Loretz Brigitta,
Hirsch Anna Katharina Herta,
Hartmann Rolf Wolfgang,
Lehr ClausMichael,
Empting Martin
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170069
Subject(s) - biofilm , pseudomonas aeruginosa , tobramycin , quorum sensing , microbiology and biotechnology , chemistry , biology , bacteria , genetics
In article number 2004369, Martin Empting and colleagues describe a new generation of dual‐loaded nanoparticles enabling efficient eradication of Pseudomonas aeruginosa biofilms. The squalene‐based nanocarrier facilitates co‐delivery of a novel pathogenspecific Quorum Sensing Inhibitor (QSI) together with the standard‐of‐care antibiotic tobramycin. The QSI itself shows high anti‐virulence efficacy, favorable DMPK and no overt safety pharmacology. When applied as the nanoparticle formulation the QSI potentiates biofilm eradication capabilities of tobramycin by at least 32‐fold.