Open AccessFerroptosis: A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome (Adv. Sci. 10/2021)
Author(s) -
Guo Jingyi,
Duan Lifan,
He Xueying,
Li Shengbiao,
Wu Yi,
Xiang Ge,
Bao Feixiang,
Yang Liang,
Shi Hongyan,
Gao Mi,
Zheng Lingjun,
Hu Huili,
Liu Xingguo
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170053
Subject(s) - mitochondrion , mutant , mitochondrial dna , organoid , microbiology and biotechnology , biology , chemistry , genetics , gene
Cover story shows the amazing Chinese story of Monkey King named Sun Wukong got the Key Stand Iron Rod in East Sea as his weapon—Gold‐Banded Cudgel. In article number 2004680, Xingguo Liu and co‐workers demonstrate a sensitivity to iron overload‐induced ferroptosis in mitochondrial DNA depletion syndrome patients, which suggests potential protective effect of mitochondria in cell from ferroptosis. In the cover, iron (Gold‐Banded Cudgel) unbalance induces ferroptosis (East Sea turbulence), which could be protected by mitochondria (Monkey King with Heart Armor).