Open AccessTargeting Multidrug‐Resistant Bacteria: Efficient Killing of Multidrug‐Resistant Internalized Bacteria by AIEgens In Vivo (Adv. Sci. 9/2021)
Author(s) -
Li Ying,
Liu Fei,
Zhang Jiangjiang,
Liu Xiaoye,
Xiao Peihong,
Bai Haotian,
Chen Shang,
Wang Dong,
Sung Simon H. P.,
Kwok Ryan T. K.,
Shen Jianzhong,
Zhu Kui,
Tang Ben Zhong
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170051
Subject(s) - bacteria , autophagy , in vivo , multiple drug resistance , microbiology and biotechnology , biology , chemistry , antibiotics , apoptosis , biochemistry , genetics
In article number 2001750, Kui Zhu, Ben Zhong Tang and co‐workers demonstrate that aggregationinduced emission luminogens such as TBPs trigger ROS‐mediated membrane damage to effectively kill internalized bacteria without resistance development. Intriguingly, TBPs promote mitochondria dependent autophagy to eliminate such bacteria in host cells. Similar to vancomycin, TBPs demonstrate high efficacy against notorious bacterial infections in vivo.