Open AccessEmbryonic Stem Cell Pluripotency: MgFe‐LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self‐Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells (Adv. Sci. 9/2021)
Author(s) -
He Xiaolie,
Zhu Yanjing,
Yang Li,
Wang Zhaojie,
Wang Zekun,
Feng Jianhao,
Wen Xuejun,
Cheng Liming,
Zhu Rongrong
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170049
Subject(s) - leukemia inhibitory factor , embryonic stem cell , microbiology and biotechnology , chemistry , stem cell , leukemia inhibitory factor receptor , biology , biochemistry , gene
In article number 2003535, Rongrong Zhu and co‐workers report the role of MgFe‐LDH nanoparticles as a promising LIF replacement in maintaining mESCs self‐renewal and pluripotency. Combined transcriptomic and proteomic analysis reveals that MgFe‐LDH could activate LIFR regulating signaling pathways, while the extra Fe 2+ provided by MgFe‐LDH also enhances TET1/2 abundance related to DNA demethylation. This biocompatible MgFe‐LDH nanoparticle favors economical and efficient replacement for LIF in large‐scale expansion of ESCs.