Open AccessMulti‐Tissue Organoid Engineering: Bio‐assembling Macro‐Scale, Lumenized Airway Tubes of Defined Shape via Multi‐Organoid Patterning and Fusion (Adv. Sci. 9/2021)
Author(s) -
Liu Ye,
Dabrowska Catherine,
Mavousian Antranik,
Strauss Bernhard,
Meng Fanlong,
Mazzaglia Corrado,
Ouaras Karim,
Macintosh Callum,
Terentjev Eugene,
Lee JooHyeon,
Huang Yan Yan Shery
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170046
Subject(s) - organoid , fusion , nanotechnology , biomedical engineering , materials science , biology , microbiology and biotechnology , medicine , linguistics , philosophy
In article number 2003332 by Joo‐Hyeon Lee, Yan Yan Shery Huang, and co‐workers, a robust organoid engineering method is developed to ‘up‐size’ and ‘shape’ organoids—miniature collections of cells which mimic biological features of an organ. The method, named Multi‐Organoid Patterning and Fusion (MOrPF), is used to assemble scaffold‐free macroscale airway tubes, leading to flowable organoid‐on‐a‐chip, and branching tubular structures. The organoid fusion process is characterised by inter‐organoid surface integration, luminal clearance, and lumina connection.