Open AccessCombination Cancer Immunotherapy: Immunogenic Cell Death Inducing Fluorinated Mitochondria‐Disrupting Helical Polypeptide Synergizes with PD‐L1 Immune Checkpoint Blockade (Adv. Sci. 7/2021)
Author(s) -
Jeong Seong Dong,
Jung BoKyeong,
Ahn Hyo Min,
Lee DaeYong,
Ha JongHoon,
Noh Ilkoo,
Yun ChaeOk,
Kim YeuChun
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170038
Subject(s) - immunogenic cell death , endoplasmic reticulum , programmed cell death , mitochondrion , cytotoxic t cell , intracellular , reactive oxygen species , immunotherapy , immune checkpoint , cancer immunotherapy , t cell , chemistry , apoptosis , blockade , immune system , microbiology and biotechnology , antibody , pd l1 , unfolded protein response , biology , immunology , receptor , biochemistry , in vitro
In article number 2001308, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop endoplasmic reticulum (ER) stress‐mediated immunogenic cell death (ICD) inducing fluorinated mitochondria‐disrupting helical polypeptides (MDHPs). These helical polypeptides destabilize the mitochondrial outer membrane, leading to the overproduction of intracellular reactive oxygen species (ROS) and ICD. In addition, co‐treatment of fluorinated MDHP and anti‐Programmed death‐ligand 1 antibodies (αPD‐L1), which block PD‐L1 on tumor cell, significantly regresses tumor growth by activating the cytotoxic T cell response.