Open AccessTheranostic Nanoparticles: Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma (Adv. Sci. 4/2021)
Author(s) -
Armanetti Paolo,
Chillà Anastasia,
Margheri Francesca,
Biagioni Alessio,
Menichetti Luca,
Margheri Giancarlo,
Ratto Fulvio,
Centi Sonia,
Bianchini Francesca,
Severi Mirko,
Traversi Rita,
Bani Daniele,
Lulli Matteo,
Del Rosso Tommaso,
Mocali Alessandra,
Rovida Elisabetta,
Del Rosso Mario,
Fibbi Gabriella,
Laurenzana Anna
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170017
Subject(s) - homing (biology) , nanoparticle , melanoma , cancer cell , cancer research , colloidal gold , tumor cells , chemistry , photoacoustic imaging in biomedicine , biophysics , nanotechnology , cancer , materials science , medicine , biology , optics , physics , ecology
In article number 2001175, Paolo Armanetti and co‐workers demonstrate the tumor‐homing efficiency and antitumoral activity of Au nanoparticles‐loaded Endothelial Colony Forming Cells (ECFCs). The image represents a cell loaded with AuNPs which acts as a Trojan horse vehicle to smuggle nearinfrared (NIR) gold nanoparticles to the tumor site. Once in the tumor tissue, these cargo cells exposed to NIR light brighten the dark battlefield and neutralize the foes (cancer cells) with their inherent strength.