Open AccessChemogenetic Manipulation: Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Life Style (Adv. Sci. 3/2021)
Author(s) -
Wang Tianlu,
He Lian,
Jing Ji,
Lan TienHung,
Hong Tingting,
Wang Fen,
Huang Yun,
Ma Guolin,
Zhou Yubin
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202170011
Subject(s) - caffeine , covid-19 , gating , life style , chemistry , necroptosis , pharmacology , microbiology and biotechnology , biology , biochemistry , medicine , programmed cell death , neuroscience , virology , apoptosis , endocrinology , disease , infectious disease (medical specialty) , environmental health , outbreak
In article number 2002148, Yubin Zhou, Guolin Ma, Yun Huang, and co‐workers developed a caffeine‐operated synthetic module (COSMO), a potent chemically‐induced dimerization system that can be switched on by caffeine and its metabolites, as well as caffeinated beverages and chocolates consumed in our daily life. COSMO enables caffeine‐inducible gating of calcium channels, activation of cell signaling, tumor cell killing via necroptosis, and enhancement of viral antigen recognition for the SARS‐CoV‐2 spike protein.