Open AccessPolyglutamic Acid‐Based Elastic and Tough Adhesive Patch Promotes Tissue Regeneration through In Situ Macrophage Modulation
Author(s) -
Zhu Qiuwen,
Hong Yi,
Huang Yuxuan,
Zhang Yi,
Xie Chang,
Liang Renjie,
Li Chenglin,
Zhang Tao,
Wu Hongwei,
Ye Jinchun,
Zhang Xianzhu,
Zhang Shufang,
Zou Xiaohui,
Ouyang Hongwei
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202106115
Subject(s) - adhesive , polyglutamic acid , regeneration (biology) , adhesion , tissue adhesion , materials science , fibrous joint , macrophage , in situ , biomedical engineering , biophysics , nanotechnology , composite material , microbiology and biotechnology , chemistry , anatomy , biochemistry , biology , in vitro , medicine , layer (electronics) , organic chemistry
Adhesive patches are advanced but challenging alternatives to suture, especially in treating fragile internal organs. So far there is no suture‐free adhesive patch based on metabolizable poly(amino acid) materials with excellent mechanical strength as well as immunomodulation functionality. Here, a polyglutamic acid‐based elastic and tough adhesive patch modified by photosensitive groups on the surface to achieve robust light‐activated adhesion and sealing of flexible internal organs is explored. With the porous internal morphology and excellent biodegradability, the patches promote regeneration through a macrophage‐regulating microenvironment. Treated rabbits achieve rapid full‐thickness gastric regeneration with complete functional structure within 14 d, suggesting its robust tissue adhesion and repair‐promoting ability.