Open AccessBioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration
Author(s) -
Li Yamin,
Chen Can,
Jiang Jia,
Liu Shengyang,
Zhang Zeren,
Xiao Lan,
Lian Ruixian,
Sun Lili,
Luo Wei,
Timyun Ong Michael,
Yukwai Lee Wayne,
Chen Yunsu,
Yuan Yuan,
Zhao Jinzhong,
Liu Changsheng,
Li Yulin
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202105945
Subject(s) - regeneration (biology) , interface (matter) , hard tissue , materials science , biomedical engineering , soft tissue , computer science , nanotechnology , human–computer interaction , engineering , composite material , medicine , dentistry , biology , surgery , microbiology and biotechnology , capillary number , capillary action
Control over soft‐to‐hard tissue interfaces is attracting intensive worldwide research efforts. Herein, a bioactive film‐guided soft–hard interface design (SHID) for multi‐tissue integrative regeneration is shown. Briefly, a soft bioactive film with good elasticity matchable to native ligament tissue, is incorporated with bone‐mimic components (calcium phosphate cement, CPC) to partially endow the soft‐film with hard‐tissue mimicking feature. The hybrid film is elegantly compounded with a clinical artificial ligament to act as a buffer zone to bridge the soft (ligament) and hard tissues (bone). Moreover, the bioactive film‐decorated ligament can be rolled into a 3D bio‐instructive implant with spatial‐controllable distribution of CPC bioactive motifs. CPC then promotes the recruitment and differentiation of endogenous cells in to the implant inside part, which enables a vascularized bone growth into the implant, and forms a structure mimicking the biological ligament–bone interface, thereby significantly improving osteointegration and biomechanical property. Thus, this special design provides an effective SHID‐guided implant‐bioactivation strategy unreached by the traditional manufacturing methods, enlightening a promising technology to develop an ideal SHID for translational use in the future.