Open AccessHuman Gut Antibiotic Resistome and Progression of Diabetes
Author(s) -
Shuai Menglei,
Zhang Guoqing,
Zeng Fangfang,
Fu Yuanqing,
Liang Xinxiu,
Yuan Ling,
Xu Fengzhe,
Gou Wanglong,
Miao Zelei,
Jiang Zengliang,
Wang Jiating,
Zhuo Laibao,
Chen Yuming,
Ju Feng,
Zheng JuSheng
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202104965
Subject(s) - resistome , antibiotics , antibiotic resistance , insulin resistance , biology , gut flora , metagenomics , type 2 diabetes , prediabetes , microbiology and biotechnology , diabetes mellitus , immunology , genetics , endocrinology , gene , integron
The antibiotic resistance crisis underlies globally increasing failures in treating deadly bacterial infections, largely due to the selection of antibiotic resistance genes (ARG) collection, known as the resistome, in human gut microbiota. So far, little is known about the relationship between gut antibiotic resistome and host metabolic disorders such as type 2 diabetes (T2D). Here, metagenomic landscape of gut antibiotic resistome is profiled in a large multiomics human cohort ( n = 1210). There is a significant overall shift in gut antibiotic resistome structure among healthy, prediabetes, and T2D groups. It is found that larger ARG diversity is associated with a higher risk of T2D. The novel diabetes ARG score is positively associated with glycemic traits. Longitudinal validation analysis confirms that the ARG score is associated with T2D progression, characterized by the change of insulin resistance. Collectively, the data describe the profiles of gut antibiotic resistome and support its close relationship with T2D progression.