Open AccessCyanine‐Doped Lanthanide Metal–Organic Frameworks for Near‐Infrared II Bioimaging
Author(s) -
Liang Tao,
Guo Zhi,
He Yifan,
Wang Yanying,
Li Chunya,
Li Zhen,
Liu Zhihong
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202104561
Subject(s) - biocompatibility , cyanine , materials science , lanthanide , metal organic framework , near infrared spectroscopy , absorption (acoustics) , doping , nanotechnology , optoelectronics , chemistry , fluorescence , optics , adsorption , ion , organic chemistry , physics , metallurgy , composite material
Developing metal–organic frameworks (MOFs) with strong near‐infrared II (NIR‐II, 1000–1700 nm) emission is significant for biomedical research but highly challenging. So far there are no MOFs reported for NIR‐II imaging in vivo due to their poor NIR‐II emission efficiency. Herein, a strategy is proposed to prepare MOFs with strong NIR‐II emission, by integrating NIR dye IR‐3C and Ln 3+ (Ln = Yb, Nd, and Er) into a same framework. IR‐3C with high photon‐absorption ability harvests the excitation photons and transfers energy to Ln 3+ via a resonance energy transfer pathway, significantly enhancing the NIR‐II emission of Ln 3+ . The as‐obtained Er‐BTC‐IR exhibits excellent NIR‐IIb (1500–1700 nm) emission efficiency in aqueous phase and good biocompatibility after surface modification, which provides advanced bioimaging performance in vivo. It is able to clearly delineate the vessels, spine, and lymph of mice, and also to differentiate the vessels with acute vascular inflammation. This strategy paves the way to the preparation of NIR‐II emissive MOFs and will promote their bioapplication.