Open AccessNanomotor‐Derived Porous Biomedical Particles from Droplet Microfluidics
Author(s) -
Liu Yuxiao,
Cheng Yi,
Zhao Cheng,
Wang Huan,
Zhao Yuanjin
Publication year - 2022
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202104272
Subject(s) - microfluidics , porosity , materials science , microcarrier , nanotechnology , biocompatibility , porous medium , bubble , microparticle , tissue engineering , drug delivery , chemical engineering , biomedical engineering , composite material , chemistry , cell , computer science , metallurgy , medicine , biochemistry , parallel computing , engineering
Porous particles have found widespread applications in therapeutic diagnosis, drug delivery, and tissue engineering due to their typical properties of large surface area, extensive loading capacity, and hierarchical microstructures. Attempts in this aspect are focusing on the development of effective methods to generate functional porous particles. Herein, a simple droplet microfluidics for continuously and directly generating porous particles by introducing bubble‐propelled nanomotors into the system is presented. As the nanomotors can continuously generate gas bubbles in the unsolidified droplet templates, the desirable porous microparticles can be obtained after droplet polymerization. It is demonstrated that the generation process is highly controlled and the resultant microparticles show excellent porosity and monodispersity. In addition, the obtained porous microparticles can serve as microcarriers for 3D cell culture, because of their characteristic porous structures and favorable biocompatibility. Moreover, owing to the existence of oxygen in these microparticles, they can be used to improve the healing effects of wounds in the type I diabetes rat models. These remarkable features of the generation strategy and the porous microparticles point to their potential values in various biomedical fields.