Open AccessPWWP2B Fine‐Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex
Author(s) -
Yan Linyu,
Jin Weiwei,
Zhao Qingwen,
Cui Xuan,
Shi Ting,
Xu Yingjiang,
Li Feiyan,
Jin Wenfang,
Zhang Zhe,
Zhang Zhao,
Tang QiQun,
Pan Dongning
Publication year - 2021
Publication title -
advanced science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.388
H-Index - 100
ISSN - 2198-3844
DOI - 10.1002/advs.202102060
Subject(s) - thermogenesis , microbiology and biotechnology , acetylation , hdac1 , histone , adipose tissue , brown adipose tissue , biology , chemistry , gene , endocrinology , genetics , histone deacetylase
Histone deacetylases (HDACs) are widely involved in many biological processes, as well as in control of brown and beige adipose physiology, but the precise molecular mechanisms by which HDACs are assembled into transcriptional machinery to fine‐tune thermogenic program remain ill‐defined. PWWP domain containing 2b (PWWP2B), which is identified as a component of the nucleosome remodeling and deacetylation complex (NuRD), interacts and stabilizes HDAC1/2 at the thermogenic gene promoters to suppress their expression. Ablation of Pwwp2b promotes adipocyte thermogenesis and ameliorates diet‐induced obesity in vivo. Intriguingly, Pwwp2b is not only a brown fat‐enriched gene but also dramatically induced by cold and sympathetic stimulation, which may serve as a physiological brake to avoid over‐activation of thermogenesis in brown and beige fat cells.